Lunenfeld-Tanenbaum Research Institute

Prosserman Centre for Population Health Research

     Selected Publications (2017 -- )

  1. C Xu, L Briollais, IL Andrulis, SB Bull. Accommodating the Analysis Model in Multiple Imputation for the Weibull Mixture Cure Model: Performance under Penalized Likelihood, Statistics in Medicine, 2026;45(6-7): e70437. http://dx.doi.org/10.1002/sim.70437 PMID: 41840351 

  2. Retnakaran R, Shen J, Hanley AJ, Zinman B. Impact of an additional pregnancy on the natural history of insulin sensitivity, beta-cell function and glycemia in parous women. Diabetes Care 2026; 49(4):664-67. doi: 10.2337/dc25-2354. PMID: 41706446
  3. Aro, R. P., Lam, S., Warkentin, M. T., Liu, G., Diergaarde, B., Wilson, D. O., Yuan, J. M., Al-Sawaihey, H., Murison, K., Khodayari Moez, E., Brhane, Y., Meza, R., Myers, R., & Hung, R. J. Integrating deep learning of low-dose computed tomography with clinical data for lung cancer risk prediction. Chest. 2026. Advance online publication. https://doi.org/10.1016/j.chest.2026.02.022 PMID: 41833807

  4. Murison KR, Warkentin MT, Khodayari Moez E, Brhane Y, Liu G, Hung RJ. Respiratory Function as a Prognostic Factor for Lung Cancer in Screening and General Populations. Ann Am Thorac Soc. 2025;22(4):591-597. doi:10.1513/AnnalsATS.202404-428OC. PMID: 39589279

  5. M Brossard, D Roshandel, K Luo, F Yavartanoo, AD Paterson, YJ Yoo, SB Bull. RegionScan: An R package for genome-wide region-based association for region detection and integration with single-variant analysis, Bioinformatics Advances, Volume 5, Issue 1, March 2025, vbaf052.  PMID: 40160476  [full texts]   

  6. Cheng S, McLaughlin JR, Brown MC, Rutka J, Bouffet E, Hawkins C, Cairney AE, Ranger A, Fleming AJ, Johnston DL, Greenberg M, Malkin D, Hung RJ. Birth characteristics and the risk of childhood brain tumors: A case-control study in Ontario, Canada. Int J Cancer. 2025 doi:10.1002/ijc.35287 PMID: 39670564 [full texts]

  7. Yavartanoo F., Brossard M., Bull SB. Dimension Reduction using Local Principal Components for Regression-based Multi-SNP Analysis in 1000 Genomes and the Canadian Longitudinal Study on Aging (CLSA), Genetic Epidemiology, 2025, 49(3): e70005. PMID: 40022577

  8. Retnakaran R, Pu J, Shen J, Hanley AJ, Zinman B. The central role of beta-cell function in the remission of prediabetes: a prospective cohort study in Canada. Lancet Diabetes Endocrinol 2025; 13(10):829-837 doi: 10.1016/S2213-8587(25)00163-9. Epub 2025 Aug 11. PMID: 40812331
  9. Sarma S, Hodzic-Santor B, Raissi A, Colacci M, Verma AA, Razak F, Højbjerg Lassen MC, Fralick M. Association of sodium glucose co-transporter-2 inhibitors with risk of diabetic ketoacidosis among hospitalized patients: A multicentre cohort study. J Diabetes Complications. 2024 Sep;38(9):108827. doi: 10.1016/j.jdiacomp.2024.108827. PMID: 39096768.

  10. Lassen MCH, Colacci M, Pareek M, Lee SG, Gislason G, Fralick M, Biering-Sørensen T. Association Between SGLT2 Inhibitor Use and Change in Hemoglobin Among Adults with Diabetes: A Nationwide Cohort Study. J Gen Intern Med. 2024 Aug;39(10):1945-1947. doi: 10.1007/s11606-024-08640-x. PMID: 38594550

  11. E Garg, P Arguello-Pascualli, O Vishnyakova, AR Halevy, S Yoo, JD Brooks, SB Bull, F Gagnon, CMT Greenwood, RJ Hung, JF Lawless, J Lerner-Ellis, JK Dennis, RJS Abraham, J-M Garant, B Thiruvahindrapuram, SJM Jones, HostSeq Implementation Committee, LJ Strug, AD Paterson, L Sun, LT Elliott. Canadian COVID-19 host genetics cohort replicates known severity associations, PLoS Genetics, 20(3), 22 March 2024, e1011192. [full texts]

  12. Wainberg, M., Forde, N.J., Mansour, S. et al. Genetic architecture of the structural connectome. Nat Commun 15, 1962 (2024). [full texts]
  13. Maan, H., Zhang, L., Yu, C, Geuenich M, Campbell K., Wang, B. Characterizing the impacts of dataset imbalance on single-cell data integration. Nat Biotechnol (2024). [full texts]  

  14. Soliman Y, Everett K, Shulman R... Weisman, A. Persistent disparities in insulin pump uptake despite a universal pump programme for type 1 diabetes in Ontario, Canada. Diabetes Obes Metab. 2024;26(10):4450-4459. [full texts] 

  15. Fang, C., Selega, A. & Campbell, K.R. Beyond benchmarking and towards predictive models of dataset-specific single-cell RNA-seq pipeline performance. Genome Biol 25, 159 (2024). [full texts]  

  16. Warkentin MT, Al-Sawaihey H, Lam S, Liu G, Diergaarde B, Yuan JM, Wilson DO, Atkar-Khattra S, Grant B, Brhane Y, Khodayari-Moez E, Murison KR, Tammemagi MC, Campbell KR, Hung RJ. Radiomics analysis to predict pulmonary nodule malignancy using machine learning approaches. Thorax 2024.doi: 10.1136/thorax-2023-220226. PMID: 38195644
  17. Geuenich, M.J., Gong, Dw. & Campbell, K.R. The impacts of active and self-supervised learning on efficient annotation of single-cell expression data. Nat Commun 15, 1014 (2024). [full texts] 

  18. Weisman A, Booth GL, Everett K, Tomlinson GA. Recent Improvements in Attainment of the Hemoglobin A1c Target of ≤7.0% Among Adults with Type 1 Diabetes in Ontario: A Retrospective Cohort Study. Diabetes Technology & Therapeutics. 2024;26(9):607-617https://doi.org/10.1089/dia.2024.0017

  19. Finegold KE, Knight JA, Hung RJ, Ssewanyana D, Wong J, Bertoni, K, Adel Khani N, Watson H, Levitan, R, Jenkins J, Matthews, S, Wade, M.. Cognitive and Emotional Well-Being of Preschool Children Before and During the COVID-19 Pandemic. JAMA Netw Open. 2023;6(11):e2343814. [full texts]

  20. Khodayari Moez E, Warkentin MT, Brhane Y, Lam S, Field JK, Liu G, Zulueta JJ, Valencia K, Mesa-Guzman M, Nialet AP, Atkar-Khattra S, Davies MPA, Grant B, Murison K, Montuenga LM, Amos CI, Robbins HA, Johansson M, Hung RJ. Circulating proteome for pulmonary nodule malignancy. J Natl Cancer Inst. 2023 Sep 7;115(9):1060-1070. [Full texts]
  21. Xu, J., Xu, W., Choi, J., Brhane, Y., Christiani, D. C., Kothari, J., McKay, J., Field, J. K., Davies, M. P. A., Liu, G., Amos, C. I., Hung, R. J., & Briollais, L. (2023). Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer. PLoS genetics19(9), e1010902.[Full texts] 

  22. C Xu, SB Bull. Penalized maximum likelihood inference under the mixture cure model in sparse data, Statistics in Medicine, 2023 Jun 15;42(13):2134-2161. PMID: 36964996
  23. Cheng, S., McLaughlin, J. R., Brown, M. C., Al-Sawaihey, H., Rutka, J., Bouffet, E., Hawkins C, Cairney AE, Ranger A, Fleming AJ, Johnston D, Greenberg M, Malkin D, Hung, R. J. (2023). Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada. British Journal of Cancer, 1–7. [Full texts]

  24. Retnakaran R, Pu J, Emery A, Harris SB, Reichert SM, Gerstein HC, McInnis N, Kramer CK, Zinman B. Determinants of sustained stabilization of beta-cell function following short-term insulin therapy in type 2 diabetes. Nat Commun 2023; 14(1):4514.[Full texts]

  25. M Brossard, AD Paterson, O Espin-Garcia, RV Craiu, SB Bull. Characterization of direct and/or indirect genetic associations for multiple traits in longitudinal studies of disease progression,Genetics, 225(1), September 2023, iyad119. PMID: 37369448

  26. Warkentin, M. T., Tammemägi, M. C., Espin-Garcia, O., Budhathoki, S., Liu, G., & Hung, R. J. (2022). Lung Cancer Absolute Risk Models for Mortality in an Asian Population using the China Kadoorie Biobank. Journal of the National Cancer Institute114(12), 1665–1673. PMID: 36083018
  27. Selega, A., Campbell, K.R., (2022) Multi-objective Bayesian Optimization with Heuristic Objectives for Biomedical and Molecular Data Analysis Workflows. bioRxiv 2022.06.08.495370 [Full texts]

  28. Retnakaran, R., Ye, C., Emery, A., Kramer, C. K., & Zinman, B. (2022). The metabolic effects of adding exenatide to basal insulin therapy when targeting remission in early type 2 diabetes in a randomized clinical trial. Nature Communications13(1), 6109. PMID: 36244997

  29. Goodwin, P.J, Chen b., Gelmon K. A., Whelan, T.J,. Ennis, M., Lemieux, J., Ligibel J.A., Hershman D.L., Mayer I.A., Hobday T.J., Bliss J.M., Rastogi P.,Rabaglio-Poretti M., Mukherjee S.D., Mackey J.R., Abramson V.G., Oja C., Wesolowski R., Thompson A.M., Rea, D.W., Stos P.M., Shepherd L.E., Stambolic V., Parulekar, W.R. (2022). Effect of metformin vs placebo on invasive disease-free survival in breast cancer: the MA.32 randomized clinical trial: the MA.32 randomized clinical trial. JAMA 327: 1963-1973. PMID: 35608580

  30. Lye, J. M., Knight, J. A., Arneja, J., Seeto, R. A., Wong, J., Adel Khani, N., Brooks, J. D., Levitan, R. D., Matthews, S. G., Lye, S. J., & Hung, R. J. (2022). Maternal acetaminophen use and cognitive development at 4 years: the Ontario Birth Study. Pediatric Research, 1–5. Advance online publication. PMID: 35794252

  31. Horwitz, J., Wen, S. W., Tan, H., Zhou, S., Ye, C., Shen, M., & Retnakaran, R. (2022). Analysis of Preconception Paternal Smoking and Neonatal Outcomes. JAMA Network Open5(1), e2144527. PMID: 35061043

  32. Cheng, S., McLaughlin, J. R., Brown, M. C., Al-Sawaihey, H., Rutka, J., Bouffet, E., Hawkins, C., Cairney, A. E., Ranger, A., Fleming, A. J., Johnston, D., Greenberg, M., Malkin, D., & Hung, R. J. (2022). Childhood head trauma and the risk of childhood brain tumours: A case-control study in Ontario, Canada. International Journal of Cancer150(5), 795–801. PMID: 34520575

  33. Zhang, C. X. W., Okeke, J. C., Levitan, R. D., Murphy, K. E., Foshay, K., Lye, S. J., Knight, J. A., & Matthews, S. G. (2022). Evaluating depression and anxiety throughout pregnancy and after birth: impact of the COVID-19 pandemic. American Journal of Obstetrics & Gynecology MFM4(3), 100605. PMID: 35257937

  34. Retnakaran, R., Ye, C., Hanley, A. J., Connelly, P. W., Sermer, M., Zinman, B., & Hamilton, J. K. (2022). Treating Gestational Diabetes Reduces Birth Weight but Does Not Affect Infant Adiposity Across the 1st Year of Life. Diabetes Care45(5), 1230–1238.  PMID: 35259243.

  35. Briollais, L., Rustand, D., Allard, C., Wu, Y., Xu, J., Rajan, S. G., Hivert, M. F., Doyon, M., Bouchard, L., McGowan, P. O., Matthews, S., & Lye, S. (2021). DNA methylation mediates the association between breastfeeding and early-life growth trajectories. Clinical Epigenetics13(1), 231. PMID: 34937578

  36. Geuenich, M. J., Hou, J., Lee, S., Ayub, S., Jackson, H. W., & Campbell, K. R. (2021). Automated assignment of cell identity from single-cell multiplexed imaging and proteomic data. Cell Systems12(12), 1173–1186.e5. PMID: 34536381.

  37. Brossard M., Paterson A.D. , Espin-Garcia, O., , Craiu R.V., Bull, S.B, . (2021) Characterization of direct and/or indirect genetic associations for multiple traits in longitudinal studies of disease progression. medRxiv 2021.05.10.21256880 [Full texts]

  38. Choi, Y. H., Terry, M. B., Daly, M. B., MacInnis, R. J., Hopper, J. L., Colonna, S., Buys, S. S., Andrulis, I. L., John, E. M., Kurian, A. W., & Briollais, L. (2021). Association of Risk-Reducing Salpingo-Oophorectomy With Breast Cancer Risk in Women With BRCA1 and BRCA2 Pathogenic Variants. JAMA Oncology7(4), 585–592. PMID: 33630024

  39. Hung, R. J., Warkentin, M. T., Brhane, Y., Chatterjee, N., Christiani, D. C., Landi, M. T., Caporaso, N. E., Liu, G., Johansson, M., Albanes, D., Marchand, L. L., Tardon, A., Rennert, G., Bojesen, S. E., Chen, C., Field, J. K., Kiemeney, L. A., Lazarus, P., Zienolddiny, S., Lam, S., … Amos, C. I. (2021). Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model. Cancer Research81(6), 1607–1615 1.  PMID: 33472890.

  40. Choi, Y. H., Terry, M. B., & Briollais, L. (2021). Bilateral Salpingo-Oophorectomy to Reduce Breast Cancer Risk in Women With Germline BRCA1 or BRCA2 Pathogenic Variants-Caution Needed-Reply. JAMA Oncology7(9), 1402. PMID: 34196652

  41. Choi, Y. H., Jung, H., Buys, S., Daly, M., John, E. M., Hopper, J., Andrulis, I., Terry, M. B., & Briollais, L. (2021). A competing risks model with binary time varying covariates for estimation of breast cancer risks in BRCA1 families. Statistical Methods in Medical Research30(9), 2165–2183. PMID: 34232831

  42. Knight, J. A., Kehm, R. D., Schwartz, L., Frost, C. J., Chung, W. K., Colonna, S., Keegan, T. H. M., Goldberg, M., Houghton, L. C., Hanna, D., Glendon, G., Daly, M. B., Buys, S. S., Andrulis, I. L., John, E. M., Bradbury, A. R., & Terry, M. B. (2021). Prepubertal Internalizing Symptoms and Timing of Puberty Onset in Girls. American Journal of Epidemiology190(3), 431–438. PMID: 33057572

  43. Espin-Garcia, O., Craiu, R. V., & Bull, S. B. (2021). Two-phase sample selection strategies for design and analysis in post-genome-wide association fine-mapping studies. Statistics in Medicine40(30), 6792–6817. PMID: 34596256

  44. Goodwin P. J. (2021). Extended Aromatase Inhibitors in Hormone-Receptor-Positive Breast Cancer. The New England Journal of Medicine385(5), 462–463. 1. PMID: 34320293.

  45. Lye JM, Knight JA, Arneja J, Seeto RA, Wong J, Adel Khani N, Brooks JD, Levitan RD, Matthews SG, Lye SJ, Hung RJ. Maternal acetaminophen use and cognitive development at 4 years: the Ontario Birth Study. Pediatr Res. 2023 Mar;93(4):959-963. doi: 10.1038/s41390-022-02182-w. PMID: 35794252

  46. Goodwin P.J., Dowling R.J.O., Ennis M., Chen B.E., Parulekar W.R., Shepherd L.E., Burnell M.J., Vandermeer R., Molckovsky A., Gurjal A., Gelmon K.A., Ligibel J.A., Hershman D., Mayer I.A., Whelan TJ, Hobday TJ, Rastogi P, Rabaglio-Poretti M, Lemieux J, Thompson AM, Rea DW, Stambolic V. (2021).  Effect of metformin on metabolic factors in MA.32 – A randomized trial in Early-Stage Breast Cancer. NPJ Breast Cancer 7, 74. [Full texts]

  47. Lohmann, A. E., Soldera, S. V., Pimentel, I., Ribnikar, D., Ennis, M., Amir, E., & Goodwin, P. J. (2021). Association of Obesity With Breast Cancer Outcome in Relation to Cancer Subtypes: A Meta-Analysis. Journal of the National Cancer Institute113(11), 1465–1475. PMID: 33620467

  48. MacInnis, R. J., Knight, J. A., Chung, W. K., Milne, R. L., Whittemore, A. S., Buchsbaum, R., Liao, Y., Zeinomar, N., Dite, G. S., Southey, M. C., Goldgar, D., Giles, G. G., Kurian, A. W., kConFab Investigators, Andrulis, I. L., John, E. M., Daly, M. B., Buys, S. S., Phillips, K. A., Hopper, J. L., … Terry, M. B. (2021). Comparing 5-Year and Lifetime Risks of Breast Cancer using the Prospective Family Study Cohort. Journal of the National Cancer Institute113(6), 785–791. PMID: 33301022

  49. Ong, S. W., Jassal, S. V., Porter, E. C., Min, K. K., Uddin, A., Cafazzo, J. A., Rac, V. E., Tomlinson, G., & Logan, A. G. (2021). Digital Applications Targeting Medication Safety in Ambulatory High-Risk CKD Patients: Randomized Controlled Clinical Trial. Clinical Journal of the American Society of Nephrology : CJASN16(4), 532–542. PMID: 33737321

  50. Pimentel I., Chen B.E, Lohmann A.E, Ennis M, Ligibel J., Shepherd L., Hershman D.L., Whelan T., Stambolic V., Mayer I., Hobday T., Lemieux J., Thompaon A., Rastogi P., Gelmon K., Rae D., Rabaglio M., Ellard S., Mates M., Bedard P., Pitre L., Vandenberg T., Dowling R.J.O., Parulekar W., Goodwin P.J. (2021). The effect of metformin on sex hormones Canadian Cancer Trials Group MA.32. J Natl Cancer Inst, 113 (2), 192-198. PMID: 33527137

  51. Retnakaran, R., Wen, S. W., Tan, H., Zhou, S., Ye, C., Shen, M., Smith, G. N., & Walker, M. C. (2021). Spousal Concordance of Cardiovascular Risk Factors in Newly Married Couples in China. JAMA Network Open4(12), e2140578. PMID: 34935919

  52. Retnakaran, R., Emery, A., Ye, C., Harris, S. B., Reichert, S. M., McInnes, N., Gerstein, H. C., Thorpe, K. E., Kramer, C. K., & Zinman, B. (2021). Short-term intensive insulin as induction and maintenance therapy for the preservation of beta-cell function in early type 2 diabetes (RESET-IT Main): A 2-year randomized controlled trial. Diabetes, Obesity & Metabolism23(8), 1926–1935. PMID: 33956387

  53. Xu, J., Xu, W., & Briollais, L. (2021). A Bayes factor approach with informative prior for rare genetic variant analysis from next generation sequencing data. Biometrics77(1), 316–328. [Full texts]

  54. Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V, Caporaso NE, Landi MT, Christiani DC, Vineis P, Liu G, Scelo G, Zaridze D, Shete SS, Albanes D, Aldrich MC, Tardón A, Rennert G, Chen C, Goodman GE, Doherty JA, Bickeböller H, Field JK, Davies MP, Dawn Teare M, Kiemeney LA, Bojesen SE, Haugen A, Zienolddiny S, Lam S, Le Marchand L, Cheng I, Schabath MB, Duell EJ, Andrew AS, Manjer J, Lazarus P, Arnold S, McKay JD, Emami NC, Warkentin MT, Brhane Y, Obeidat M, Martin RM, Relton C, Davey Smith G, Haycock PC, Amos CI, Brennan P, Witte JS*, Hung RJ*. (2020). Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nature Communications 11(1):27. PMID: 31911640

  55. Zhang, A. W., & Campbell, K. R. (2020). Computational modelling in single-cell cancer genomics: methods and future directions. Physical Biology17(6), 061001. 1. PMID: 32759485.

  56. Romanescu, R. G., Green, J., Andrulis, I. L., & Bull, S. B. (2020). Gene-based and pathway-based testing for rare-variant association in affected sib pairs. Genetic Epidemiology44(4), 368–381 PMID: 32237178

  57. Casas-Guzik, L., Ye, C., & Retnakaran, R. (2020). Association of Time With Reliability of Maternal Recall of Infant Birth Weight. JAMA Pediatrics174(12), 1208–1210. PMID: 32364580

  58. Goodwin, P. J., Segal, R. J., Vallis, M., Ligibel, J. A., Pond, G. R., Robidoux, A., Findlay, B., Gralow, J. R., Mukherjee, S. D., Levine, M., & Pritchard, K. I. (2020). The LISA randomized trial of a weight loss intervention in postmenopausal breast cancer. NPJ Breast Cancer6, 6. PMID: 32133391

  59. Lakhal-Chaieb, L., Simard, J., & Bull, S. (2020). Sequence kernel association test for survival outcomes in the presence of a non-susceptible fraction. Biostatistics (Oxford, England)21(3), 518–530. 1. PMID: 30590388.

  60. Michalsky, C.A., Hung, R.J., Seeto R. A, Dennis, C-L, Brooks JD, Henderson J, Levitan R, Lye SJ, Matthews S, Knight, J.A. (2020).Maternal cannabis use and adverse birth outcomes. BMC Pregnancy Childbirth 20(1):771. PMID: 33308186

  61. Wu, Y., Lye, S., Dennis, C. L., & Briollais, L. (2020). Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort. PLoS Genetics16(6), e1008790. PMID: 32525877

  62. Retnakaran, R., & Shah, B. R. (2020). Divergent Trajectories of Cardiovascular Risk Factors in the Years Before Pregnancy in Women With and Without Gestational Diabetes Mellitus: A Population-Based Study. Diabetes Care43(10), 2500–2508. PMID: 32796027

  63. Zhang, A. W., O'Flanagan, C., Chavez, E. A., Lim, J. L. P., Ceglia, N., McPherson, A., Wiens, M., Walters, P., Chan, T., Hewitson, B., Lai, D., Mottok, A., Sarkozy, C., Chong, L., Aoki, T., Wang, X., Weng, A. P., McAlpine, J. N., Aparicio, S., Steidl, C., Campbell, K.R., Shah, S. P. (2019). Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling. Nature Methods16(10), 1007–1015. PMID: 31501550

  64. Campbell, K. R., Steif, A., Laks, E., Zahn, H., Lai, D., McPherson, A., Farahani, H., Kabeer, F., O'Flanagan, C., Biele, J., Brimhall, J., Wang, B., Walters, P., IMAXT Consortium, Bouchard-Côté, A., Aparicio, S., & Shah, S. P. (2019). clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers. Genome Biology20(1), 54. PMID: 30866997

  65. Warkentin, M. T., Lam, S., & Hung, R. J. (2019). Determinants of impaired lung function and lung cancer prediction among never-smokers in the UK Biobank cohort. EBioMedicine47, 58–64. PMID: 31495719

  66. Choi, Y. H., Lakhal-Chaieb, L., Kröl, A., Yu, B., Buchanan, D., Ahnen, D., Le Marchand, L., Newcomb, P. A., Win, A. K., Jenkins, M., Lindor, N. M., & Briollais, L. (2019). Risks of Colorectal Cancer and Cancer-Related Mortality in Familial Colorectal Cancer Type X and Lynch Syndrome Families. Journal of the National Cancer Institute111(7), 675–683. 8. PMID: 30380125

  67. Dowling, R.J.O., Kalinsky, K., Hayes, D.F., Bidard, F-C., Cescon, D.W., Chandarlapaty, S., Deasy, J.O., Dowsett, M., Gray, R.J., Henry, N.L., Meric-Bernstam, F., Perlmutter, J., Sledge, G.W., Bratman, S.V., Carey, L.A., Chang, M.C., DeMichele, A., Ennis, M., Jerzak, K.J., Korde, L.A., Lohmann, A.E., Mamounas E.P., Parulekar, W.R., Regan, M.M., Schramek, D., Stambolic, V., Thorat, M.A., Whelan, T.J., Wolff, AC., Woodgett, J.R., Sparano, J.A., Goodwin, P.J. (2019). Toronto workshop on late recurrence in estrogen receptor positive breast cancer Part 1: Late recurrence – current understanding, clinical considerations. Journal of the National Cancer Institute Cancer Spectrum 3(4), pkz050.  PMID: 32337479

  68. Houghton, L. C., Knight, J. A., Wei, Y., Romeo, R. D., Goldberg, M., Andrulis, I. L., Bradbury, A. R., Buys, S. S., Daly, M. B., John, E. M., Chung, W. K., Santella, R. M., Stanczyk, F. Z., & Terry, M. B. (2019). Association of Prepubertal and Adolescent Androgen Concentrations With Timing of Breast Development and Family History of Breast Cancer. JAMA Network Open2(2), e190083. PMID: 30794303 PMID: 30794303

  69. Kim, S. A., Brossard, M., Roshandel, D., Paterson, A. D., Bull, S. B., & Yoo, Y. J. (2019). gpart: human genome partitioning and visualization of high-density SNP data by identifying haplotype blocks. Bioinformatics (Oxford, England)35(21), 4419–4421.  PMID: 31070701

  70. Retnakaran, R., & Shah, B. R. (2019). Glucose screening in pregnancy and future risk of cardiovascular disease in women: a retrospective, population-based cohort study. The Lancet. Diabetes & Endocrinology7(5), 378–384. PMID: 30928459

  71. Stock, D., Knight, J. A., Raboud, J., Cotterchio, M., Strohmaier, S., Willett, W., Eliassen, A. H., Rosner, B., Hankinson, S. E., & Schernhammer, E. (2019). Rotating night shift work and menopausal age. Human Reproduction (Oxford, England)34(3), 539–548. PMID: 30753548

  72. Retnakaran, R., Ye, C., Hanley, A. J., Connelly, P. W., Sermer, M., & Zinman, B. (2019). Screening Glucose Challenge Test in Pregnancy Can Identify Women With an Adverse Postpartum Cardiovascular Risk Factor Profile: Implications for Cardiovascular Risk Reduction. Journal of the American Heart Association8(21), e014231. PMID: 31657272

  73. Shen SY, Singhanai R, Fehringer G, Chakravarthy A, Roehrl MHA, Chadwick D, Zuzarte PC, Borgida A, Wang TT, Li T, Kis O, Zhao Z, Spreafico A, da Silva Medina T, Wang Y, Roulois D, Ettayebi I, Chen Z, Chow S, Murphy T, Arrudal A, O'Kane GM, Liu J, Mansour M, McPherson JD, O'Brien C, Leigh N, Bedard PL, Fleshner N, Liu G, Minden MD, Gallinger S, Goldenberg A, Pugh TJ, Hoffman MM, Bratman SV, Hung RJ*, DeCarvalho DD*.(2018). Highly sensitive tumor detection and classification using methylome analysis of plasma cell-free DNA.  Nature, 563(7732):579-583. PMID: 30429608

  74. Anderson, L. N., Knight, J. A., Hung, R. J., Hewko, S. L., Seeto, R. A., Martin, M. J., Fleming, A., Maguire, J. L., Matthews, S. G., Murphy, K. E., Okun, N., Jenkins, J. M., Lye, S. J., Bocking, A., & Ontario Birth Study Collaboration (2018). The Ontario Birth Study: A prospective pregnancy cohort study integrating perinatal research into clinical care. Paediatric and Perinatal Epidemiology32(3), 290–301. PMID: 29750375

  75. Bull, S.B., Andrulis, I.L., Paterson. A.D. (2018). Statistical Challenges in High-Dimensional Molecular and Genetic Epidemiology. Canadian Journal of Statistics, 46(1): 24-49. [Full text]

  76. Kachuri L, Saarela O, Bojesen SE, Davey Smith G, Liu G, Landi MT, Caporaso NE, Christiani DC, Johansson M, Panico S, Overvad K, Trichopoulou A, Vineis P, Scelo G, Zaridze D, Wu X, Albanes D, Diergaarde B, Lagiou P, Macfarlane GJ, Aldrich MC, Tardón A, Rennert G, Olshan AF, Weissler MC, Chen C, Goodman GE, Doherty JA, Ness AR, Bickeböller H, Wichmann HE, Risch A, Field JK, Teare MD, Kiemeney LA, van der Heijden EHFM, Carroll JC, Haugen A, Zienolddiny S, Skaug V, Wünsch-Filho V, Tajara EH, Ayoub Moysés R, Daumas Nunes F, Lam S, Eluf-Neto J, Lacko M, Peters WHM, Le Marchand L, Duell EJ, Andrew AS, Franceschi S, Schabath MB, Manjer J, Arnold S, Lazarus P, Mukeriya A, Swiatkowska B, Janout V, Holcatova I, Stojsic J, Mates D, Lissowska J, Boccia S, Lesseur C, Zong X, McKay JD, Brennan P, Amos CI, Hung RJ. (2018). Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers.  Int. J. Epidemiology, 48(3), 751-766. PMID: 30059977

  77. Knight, J. A., Blackmore, K. M., Fan, J., Malone, K. E., John, E. M., Lynch, C. F., Vachon, C. M., Bernstein, L., Brooks, J. D., Reiner, A. S., Liang, X., Woods, M., WECARE Study Collaborative Group, & Bernstein, J. L. (2018). The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study. Breast Cancer Research : BCR20(1), 23. PMID: 29566728

  78. Logan, A. G., & Jassal, S. V. (2018). Building a Stronger Care Loop Through mHealth Technology. JAMA Internal Medicine178(6), 809–811. PMID: 29710104.

  79. Retnakaran, R., Wen, S. W., Tan, H., Zhou, S., Ye, C., Shen, M., Smith, G. N., & Walker, M. C. (2018). Association of Timing of Weight Gain in Pregnancy With Infant Birth Weight. JAMA Pediatrics172(2), 136–142. PMID: 29279903

  80. McKay JD*, Hung RJ*, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV; SpiroMeta Consortium, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI. (2017). Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nature Genetics. 49(7):1126-1132. PMID: 28604730

  81. Briollais, L., Ozcelik, H., Xu, J., Kwiatkowski, M., Lalonde, E., Sendorek, D. H., Fleshner, N. E., Recker, F., Kuk, C., Olkhov-Mitsel, E., Savas, S., Hanna, S., Juvet, T., Hunter, G. A., Friedlander, M., Li, H., Chadwick, K., Prassas, I., Soosaipillai, A., Randazzo, M., … Zlotta, A. R. (2017). Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer. Journal of the National Cancer Institute109(4), 10.1093/jnci/djw258. 1.    PMID: 28376164

  82. Knight, J. A., Fan, J., Malone, K. E., John, E. M., Lynch, C. F., Langballe, R., Bernstein, L., Shore, R. E., Brooks, J. D., Reiner, A. S., Woods, M., Liang, X., Bernstein, J. L., & WECARE Study Collaborative Group (2017). Alcohol consumption and cigarette smoking in combination: A predictor of contralateral breast cancer risk in the WECARE study. International Journal of Cancer141(5), 916–924. PMID: 28524234

  83. Wu, Y. Y., Lye, S., & Briollais, L. (2017). The role of early life growth development, the FTO gene and exclusive breastfeeding on child BMI trajectories. International Journal of Epidemiology46(5), 1512–1522. PMID: 29040503

  84. Yoo, Y. J., Sun, L., Poirier, J. G., Paterson, A. D., & Bull, S. B. (2017). Multiple linear combination (MLC) regression tests for common variants adapted to linkage disequilibrium structure. Genetic Epidemiology41(2), 108–121. PMID: 27885705

  85. Zong, X., Pole, J. D., Grundy, P. E., Mahmud, S. M., Parker, L., & Hung, R. J. (2017). Second malignant neoplasms after childhood non-central nervous system embryonal tumours in North America: A population-based study. European Journal of Cancer (Oxford, England)84, 173–183.  PMID: 28822326